Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-citrulline is a non-essential amino acid that is commonly found in watermelon and is produced naturally in the body. Its primary role in muscle tone and function is attributed to its involvement in the urea cycle and its ability to increase arginine levels, which in turn enhances nitric oxide (NO) production. Nitric oxide is a key molecule that promotes vasodilation and improved blood flow, which is crucial during exercise and muscle activity.

Several clinical studies suggest that supplementation with L-citrulline can improve exercise performance and reduce muscle soreness. For example, research published in the Journal of Strength and Conditioning Research has shown that L-citrulline supplementation before exercise can lead to increased repetitions during resistance training and reduced muscle fatigue. These effects are believed to be mediated by enhanced delivery of oxygen and nutrients to muscle tissue, as well as improved removal of metabolic waste products.

However, while there is evidence that L-citrulline can improve aspects of muscle performance, there is less direct evidence regarding its effects specifically on muscle tone in non-athletic populations or in those with clinical muscle tone deficiencies. Most benefits are observed in the context of exercise-induced muscle fatigue rather than chronic muscle hypotonia. As such, the evidence supporting its use for improving muscle tone specifically is moderate, justifying a rating of 3 out of 5.

More about L-citrulline
More about Muscle Tone (lack of)

Other ingredients used for Muscle Tone (lack of)

Other health conditions supported by L-citrulline

Products containing L-citrulline

Nature's Sunshine Solstic Cardio