Flavonols, a subgroup of flavonoids found in many fruits and vegetables (notably quercetin and kaempferol), have been the subject of increasing scientific investigation for their effects on mitochondrial function. Several preclinical studies suggest that flavonols possess antioxidant properties that help protect mitochondria from oxidative stress—a key factor in mitochondrial dysfunction and related diseases. Flavonols have been shown to improve mitochondrial biogenesis, enhance energy metabolism, and reduce mitochondrial damage in cellular and animal models. For example, quercetin has demonstrated the ability to upregulate genes associated with mitochondrial biogenesis (such as PGC-1α) and improve mitochondrial performance in muscle and neural tissues in rodents. Additionally, some studies have found that flavonol supplementation can improve mitochondrial function in models of neurodegenerative diseases and metabolic syndrome.

However, despite promising preclinical findings, robust clinical trials in humans are limited. Most human studies focus on general antioxidant or cardiovascular benefits rather than direct measures of mitochondrial health. Thus, while the use of flavonols to support mitochondrial function is grounded in scientific rationale and supported by preliminary laboratory evidence, clinical validation is still emerging. As such, flavonols are scientifically justified for mitochondrial support, but the evidence base is moderate rather than strong.