Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Amino acids are scientifically validated as important for mitochondrial function. Mitochondria are the energy-producing organelles in cells, and several amino acids play direct and indirect roles in supporting their function. For example, amino acids such as glutamine, glycine, and serine are substrates for the synthesis of key mitochondrial proteins and for the production of molecules like glutathione, an important antioxidant that protects mitochondria from oxidative stress. Branched-chain amino acids (BCAAs) are also involved in energy metabolism within mitochondria, particularly in muscle tissue. Research has shown that amino acid supplementation can improve mitochondrial biogenesis and function, especially in the context of metabolic diseases, muscle wasting, and aging. However, while the mechanistic role of amino acids in mitochondrial health is well-established, clinical evidence supporting direct supplementation for general mitochondrial support in healthy individuals is limited and often context-dependent. Most studies focus on disease states or specific deficiencies rather than routine supplementation. Therefore, the evidence is moderate (rated 3/5): amino acids are essential for mitochondrial health, and supplementation may be beneficial in particular situations, but there is not yet strong evidence to support widespread use specifically for mitochondrial support in healthy populations.

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