Evidence supporting the use of: Vitamin D3
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D3 has been investigated as a potential adjunct in the management of migraine, and there is emerging but limited scientific evidence to support its use. Several observational studies have found an association between low vitamin D levels and increased prevalence or severity of migraine. Some small randomized controlled trials (RCTs) have suggested that vitamin D supplementation may reduce the frequency and severity of migraine attacks, particularly in individuals with vitamin D deficiency. For example, a 2019 double-blind RCT published in Headache found that daily supplementation with 2,000 IU of vitamin D3 for 24 weeks resulted in a significant reduction in headache frequency compared to placebo, especially in patients who had low baseline levels of vitamin D. Proposed mechanisms include vitamin D’s anti-inflammatory properties, its role in modulating neuronal excitability, and its effects on neurotransmitter regulation.

However, the current body of evidence is still limited by small sample sizes, short follow-up periods, and heterogeneity in dosage and patient populations. Not all studies have found a significant benefit, and there is no consensus on optimal dosing or specific patient groups who might benefit most. Most clinical guidelines do not currently recommend vitamin D3 as a standard treatment for migraine, though it may be considered in patients with documented deficiency. In summary, while there is some scientific basis for the use of vitamin D3 in migraine prevention, the overall evidence is preliminary and further large-scale, high-quality studies are needed.

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Other ingredients used for Migraine

1,3,7-Trimethylpurine-2,6-dione
5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone