Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Stephania root, particularly from species such as Stephania tetrandra and Stephania japonica, has a history of use in traditional medicine systems, especially in Traditional Chinese Medicine (TCM) and some Southeast Asian herbal practices. In TCM, Stephania (often referred to as "Fang Ji") is used as part of herbal formulas to help "clear heat," "expel wind," and "relieve pain," which may include symptoms like fever, inflammation, and swelling. The conceptual framework of TCM does not always align directly with modern biomedical definitions of fever, but the historical texts indicate its use for conditions that present with elevated body temperature or feverish sensations.

Scientific validation for its use specifically in the treatment or management of fever is limited. Some studies have investigated the anti-inflammatory and immunomodulatory properties of alkaloids found in Stephania root, such as tetrandrine, but these are generally focused on broader effects like anti-inflammatory or antihypertensive activity rather than direct antipyretic (fever-reducing) effects. As of now, there are no high-quality clinical trials or robust preclinical data directly supporting Stephania root's efficacy in treating fever in humans. Thus, its use for fever rests mainly on traditional practices and anecdotal accounts rather than established scientific evidence.

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