Synopsis

Source of validity: Scientific
Rating (out of 5): 3

DHEA (dehydroepiandrosterone) is a steroid hormone produced naturally by the adrenal glands and serves as a precursor to both androgens and estrogens. Its supplementation has been investigated in the context of female reproductive health, particularly for women with diminished ovarian reserve or those undergoing assisted reproductive technologies like in vitro fertilization (IVF). Scientific studies, including randomized controlled trials and meta-analyses, suggest that DHEA supplementation may improve ovarian response, increase the number of retrieved oocytes, and potentially enhance pregnancy rates in women with poor ovarian reserve. Proposed mechanisms include improved follicular environment and enhanced androgenic support for folliculogenesis. However, the quality of evidence is moderate, with some studies showing benefit and others reporting minimal or no effect. The largest and most rigorous trials have yet to provide conclusive evidence for widespread clinical use. Additionally, DHEA is not universally recommended in reproductive medicine guidelines, and long-term safety data are limited, particularly concerning hormone-sensitive conditions. In summary, while there is scientific interest and some supporting evidence for DHEA’s use in female reproductive support, especially among women with specific fertility challenges, the evidence is mixed and not yet strong enough for universal endorsement. Women considering DHEA supplementation should consult with a reproductive endocrinologist to weigh potential benefits and risks.

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Products containing DHEA (dehydroepiandrosterone)

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Nature's Sunshine DHEA-F
Nature's Sunshine DHEA-M
Nature's Sunshine Men's X-Action Reloaded