Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid found primarily in marine sources such as fish oil. There is moderate scientific evidence supporting its role in eye health, particularly for its anti-inflammatory properties. EPA, often combined with docosahexaenoic acid (DHA), has been studied for its impact on dry eye syndrome and age-related macular degeneration (AMD). The Age-Related Eye Disease Study 2 (AREDS2), a large randomized controlled trial, evaluated supplementation with EPA and DHA in addition to other nutrients for AMD. While the addition of EPA and DHA did not provide statistically significant additional benefit for AMD progression compared to the original AREDS formulation, some secondary analyses and smaller studies suggest omega-3s may help reduce symptoms of dry eye disease, likely due to their ability to modulate inflammation and support tear production.

Professional organizations like the American Academy of Ophthalmology acknowledge the potential benefits of omega-3 supplementation for dry eye, but note that evidence is mixed and more research is needed. Overall, the use of EPA for eye health is scientifically plausible, especially in the context of anti-inflammatory effects, but the clinical evidence is moderate and not definitive for all eye conditions. EPA is not a cure-all, but may be useful as part of a broader strategy for supporting ocular surface health.

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Products containing EPA (eicosapentaenoic acid)

Nature's Sunshine Circulatory System
Nature's Sunshine DHA
Nature's Sunshine Krill Oil (With Vitamin K2)
Nature's Sunshine Super Omega 3 EPA
Nature's Sunshine Super Omega 3 EPA
Nature's Sunshine Super Trio