Evidence supporting the use of: Vitamin B12
For the health condition: Endurance (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B12 is commonly used to support endurance, particularly in the context of individuals experiencing fatigue or low energy. The justification for its use primarily stems from its well-established role in red blood cell formation and neurological function. B12 deficiency can lead to megaloblastic anemia, which manifests as fatigue, weakness, and reduced exercise tolerance. For individuals with a documented B12 deficiency—such as vegetarians, older adults, or those with conditions affecting absorption—supplementation can correct anemia and improve energy levels, indirectly supporting endurance. However, in healthy individuals with normal B12 status, scientific studies do not consistently show that additional B12 supplementation enhances endurance or athletic performance. A review of the literature (Woolf & Manore, 2006; Medicine & Science in Sports & Exercise) indicates that while B12 is essential for normal energy metabolism, no significant ergogenic (performance-enhancing) effect has been observed in non-deficient populations. Therefore, while there is a strong scientific rationale for using B12 to treat endurance problems related to deficiency, there is minimal evidence to support its use for improving endurance in the general, well-nourished population. In summary, B12 supplementation is scientifically validated for the treatment of endurance issues caused by deficiency but not for general enhancement of endurance.

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