Evidence supporting the use of: L-tyrosine
For the body system: Dopamine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-tyrosine is an amino acid precursor to catecholamine neurotransmitters, including dopamine, norepinephrine, and epinephrine. Its use to support the "dopamine body system" stems from its role in the biosynthetic pathway: L-tyrosine is converted by the enzyme tyrosine hydroxylase into L-DOPA, which is subsequently converted into dopamine. Scientific studies have explored whether supplementing with L-tyrosine can increase dopamine synthesis, especially under conditions of acute stress, fatigue, or cognitive demand, when neurotransmitter reserves may become depleted.

Randomized controlled trials in humans have shown that tyrosine supplementation can improve cognitive performance and working memory during stressors such as cold exposure, sleep deprivation, or demanding mental tasks, suggesting a protective effect on neurotransmitter function. However, evidence that tyrosine supplementation boosts baseline dopamine levels or has a meaningful effect in healthy, unstressed individuals is limited. There is also no strong evidence that tyrosine supplementation is effective in treating dopamine-related disorders such as depression or Parkinson’s disease.

Overall, the scientific evidence supports a modest benefit of L-tyrosine in preventing neurotransmitter depletion and supporting cognitive function under acute stress, but does not robustly support its use for general dopamine “support” in all situations. Thus, its evidence rating for this use is moderate but not strong.

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