Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bifidobacterium (mixed strains) has scientific support for use in treating constipation in children. Several randomized controlled trials and systematic reviews have investigated the efficacy of probiotics, including mixed Bifidobacterium species, in pediatric constipation. A 2017 systematic review published in Alimentary Pharmacology & Therapeutics found modest but statistically significant improvements in stool frequency among children receiving probiotics compared to placebo, with Bifidobacterium-containing mixtures among those studied. Another 2017 meta-analysis in Journal of Pediatric Gastroenterology and Nutrition concluded that probiotics, particularly mixtures containing Bifidobacterium, increased stool frequency in constipated children, though effects on stool consistency and pain were less consistent. The proposed mechanisms include modulation of gut microbiota, production of short-chain fatty acids, and improved intestinal motility. However, not all studies are positive; some have failed to demonstrate significant benefit, and heterogeneity in probiotic strains and dosages complicates interpretation. While guidelines such as those from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) do not universally recommend probiotics as first-line therapy, they acknowledge their potential as adjunctive treatment. In summary, there is moderate scientific evidence that mixed Bifidobacterium probiotics may support increased stool frequency in children with constipation, but further well-designed studies are needed to clarify optimal strains and regimens.

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