Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bacillus subtilis is a spore-forming probiotic bacterium that has been investigated for its effects on gastrointestinal health, including constipation in adults. The scientific evidence supporting its use for constipation is modest but growing. Several small-scale clinical trials and animal studies suggest that B. subtilis may help regulate bowel movements and improve stool consistency by modulating intestinal microflora and enhancing gut motility. For instance, a 2021 randomized controlled trial found that a multi-strain probiotic supplement containing B. subtilis significantly improved stool frequency and consistency in adults with functional constipation compared to placebo. Animal studies also indicate that B. subtilis supplementation can increase short-chain fatty acid production, which may stimulate peristalsis. However, the evidence base is limited by small sample sizes, short study durations, and the frequent use of multi-strain formulations, making it difficult to ascribe effects specifically to B. subtilis. There is also variability in strains used and dosing. While some guidelines and reviews cautiously support the use of certain probiotics for constipation, B. subtilis is not universally recommended as a first-line treatment due to insufficient high-quality, strain-specific data. In summary, scientific evidence for B. subtilis in the treatment of adult constipation exists but is of low to moderate strength, warranting a rating of 2/5. More large-scale, well-designed clinical trials are needed to clarify its efficacy and optimal use for this condition.

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Other ingredients used for Constipation (adults)

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Products containing bacillus subtilis

Nature's Sunshine AIVIA Performance Probiotic