Evidence supporting the use of: Citrus bioflavonoids
For the health condition: Colds (prevention)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Citrus bioflavonoids, found in citrus fruits such as oranges, lemons, and grapefruits, have a long history of traditional use in folk medicine to support immune health and prevent or treat the common cold. The rationale behind their use stems from early 20th-century observations that diets rich in citrus fruits seemed to correlate with fewer colds and improved overall health. Bioflavonoids were believed to enhance the effects of vitamin C, another popular remedy for colds, by improving its absorption and stability in the body, as well as by providing antioxidant effects that might support immune function. However, despite these traditional beliefs, scientific research into the efficacy of citrus bioflavonoids for cold prevention is limited and inconclusive. Most studies have focused on vitamin C rather than bioflavonoids themselves. Some laboratory research suggests that bioflavonoids possess antioxidant and anti-inflammatory properties, and they may modulate immune cell activity, but direct clinical evidence for cold prevention is lacking. Reviews and clinical trials examining flavonoids in general (not specifically citrus bioflavonoids) show potential for reduced incidence or duration of upper respiratory tract infections, but the evidence is not strong or specific enough to make firm recommendations. In summary, the use of citrus bioflavonoids for cold prevention is primarily based on traditional use, with limited scientific support.

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