Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Oligomeric proanthocyanidins (OPCs), which are polyphenolic compounds found in foods such as grapes, pine bark (Pycnogenol), and some berries, have scientific evidence supporting their use in supporting the capillary system. Their primary mechanism relates to strengthening capillary walls and enhancing vascular integrity. Several clinical and preclinical studies indicate that OPCs can reduce capillary permeability and fragility, leading to decreased edema, bruising, and symptoms associated with venous insufficiency.

A major review published in Phytotherapy Research (2015) summarizes that OPCs possess significant antioxidant activity, which protects endothelial cells from oxidative stress, a key factor in capillary damage. Additionally, randomized controlled trials (RCTs) using standardized grape seed extract and Pycnogenol have demonstrated reduced capillary leakage and improved microcirculation in patients with chronic venous insufficiency and related conditions. For example, a double-blind RCT (Cesarone et al., 2005) showed that Pycnogenol supplementation significantly decreased capillary permeability and improved symptoms of venous disorders.

While more large-scale human trials would further strengthen the evidence, current research supports the use of OPCs for capillary support due to their vascular protective properties and consistent findings in clinical studies. Thus, the use of oligomeric proanthocyanidins for supporting capillaries is based primarily on scientific validation.

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