Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Chlorophyllin, a water-soluble derivative of chlorophyll, has been used traditionally as a topical agent to promote wound healing and reduce odor, including in oral lesions such as canker sores (aphthous ulcers). The historical basis for its use comes primarily from clinical practice in the mid-20th century, when chlorophyllin was included in ointments and mouth rinses for various wounds and ulcers. Several small studies and case reports from the 1940s to 1960s suggested that chlorophyllin might aid healing and reduce pain in oral ulcers, but these were not large, well-controlled studies by modern standards.

The proposed mechanisms for chlorophyllin’s effect include its purported anti-inflammatory, antimicrobial, and deodorizing properties, which might contribute to a more favorable environment for mucosal healing. However, there is little contemporary scientific research specifically addressing chlorophyllin’s effectiveness for canker sores. Systematic reviews and modern clinical guidelines do not mention chlorophyllin as a recommended treatment, and there is a lack of robust, high-quality clinical trials validating its use for this specific indication.

In summary, the use of chlorophyllin for canker sores is primarily based on traditional use and historical reports, with limited and low-quality scientific evidence supporting its efficacy. More rigorous clinical research would be needed to justify its widespread recommendation for this purpose.

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