Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Undecylenic Acid for Athlete's Foot: Scientific Evidence

Undecylenic acid is a fatty acid derived from castor oil, and it has been widely used as a topical antifungal agent, especially in the treatment of Athlete's Foot (tinea pedis). There is a robust body of scientific evidence and regulatory approval supporting its efficacy. The United States Food and Drug Administration (FDA) has recognized undecylenic acid and its salts as safe and effective over-the-counter (OTC) treatments for superficial fungal infections, including Athlete's Foot. The mechanism of action involves disruption of fungal cell membranes, inhibiting the growth of dermatophytes such as Trichophyton species, which are the main causative agents of Athlete's Foot.

Numerous in vitro studies have demonstrated the antifungal activity of undecylenic acid against a range of pathogenic fungi. Clinical studies, though somewhat dated, report significant improvement in symptoms and reduction in fungal load when applied topically. For example, a 1950s study published in JAMA showed undecylenic acid preparations were as effective as other topical antifungals of the era. More recent reviews and laboratory studies confirm its continued efficacy and safety profile.

Given its FDA approval, long-standing clinical use, and demonstrated antifungal properties, the use of undecylenic acid for Athlete's Foot is primarily justified by scientific evidence. However, it is generally used for mild to moderate cases, and persistent or severe infections may require additional or systemic treatments.

More about Undecylenic acid
More about Athlete's Foot

Other ingredients used for Athlete's Foot

Other health conditions supported by Undecylenic acid

Products containing Undecylenic acid