Evidence supporting the use of: Selenium
For the health condition: Arrhythmia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Selenium is an essential trace element known for its role in antioxidant defense and thyroid hormone metabolism. Its use in arrhythmia is primarily supported by scientific investigation, although the strength of evidence is limited. Selenium deficiency has been linked to certain types of cardiac dysfunction, notably Keshan disease, a form of cardiomyopathy seen in selenium-deficient regions, which can present with arrhythmias. Several studies have observed that low selenium status may contribute to increased oxidative stress and damage to cardiac tissue, potentially predisposing individuals to arrhythmias.

However, clinical trials directly evaluating selenium supplementation for the prevention or treatment of arrhythmias in the general population are scarce. Most evidence comes from observational studies or from populations with profound selenium deficiency. Some small interventional studies suggest that selenium, often in combination with other antioxidants or micronutrients, may help reduce arrhythmic events, particularly in patients with heart failure or those undergoing cardiac surgery, but results are inconsistent. Major cardiology guidelines do not recommend selenium supplementation for arrhythmia prevention or treatment except in cases of proven deficiency.

In summary, while there is a biological rationale and some clinical evidence linking selenium status to arrhythmia risk, the overall quality and quantity of evidence is low (rated 2/5). Selenium supplementation may be justified in cases of deficiency, but its routine use for arrhythmia is not broadly supported by strong scientific data.

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