Evidence supporting the use of: Boronic acid analogues
For the health condition: Antibiotics (alternatives to)
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Boronic acid analogues are scientifically validated as effective agents, particularly as alternatives or adjuncts to traditional antibiotics. Their primary mechanism involves the inhibition of serine β-lactamases, which are enzymes produced by certain bacteria to resist β-lactam antibiotics (such as penicillins and cephalosporins). Notably, the boronic acid-based compound vaborbactam, in combination with meropenem, has been approved for clinical use and demonstrates potent activity against carbapenem-resistant Enterobacteriaceae (CRE). The scientific justification for their use is robust; multiple peer-reviewed studies have shown that boronic acid derivatives can restore the efficacy of β-lactam antibiotics against resistant bacterial strains. They act as reversible, covalent inhibitors of the active site serine in β-lactamases, thereby protecting the antibiotic from degradation. While boronic acids themselves are not typically used as standalone antibiotics, their role as β-lactamase inhibitors is well established and supported by preclinical, clinical, and pharmacological evidence. As resistance to conventional antibiotics rises, boronic acid analogues represent a key innovation in antibiotic adjuvant therapy, with ongoing research exploring their utility against a broader spectrum of bacterial enzymes and pathogens.
More about Boronic acid analogues
More about Antibiotics (alternatives to)
Other ingredients used for Antibiotics (alternatives to)
2'-Fucosyllactoseajoene
astragalus
bacillus clausii
bacillus subtilis
berberine
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caprylic acid
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colostrum
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turmeric
curcumin
epigallocatechin gallate (EGCG)
garlic bulb
ginger
goldenseal
gooseberry
green tea
horseradish
Indian tinospora
honeysuckle
lactobacillus bulgaricus
lactobacillus fermentum
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lactococcus lactis
lactoferrin
lactoperoxidase
lauric acid
lentinula edodes mycelia
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monolaurin
oregano
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melaleuca alternifolia
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Andrographolide
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Allyl Sulfide
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Betulinic acid
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benzyl isothiocyanate
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Eugenol
Flavonoids
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Other health conditions supported by Boronic acid analogues
Antibiotics (alternatives to)Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Chemotherapy (reducing side effects)
Diabetes
Infection (bacterial)
Inflammation
