Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Bishop's Weed (botanical name: Ammi visnaga) has a longstanding history of traditional use for cardiovascular conditions, particularly angina pectoris, in Unani and traditional Mediterranean medicine. The key active compounds in Bishop's Weed, such as khellin and visnagin, were historically observed to have vasodilatory effects. These compounds are believed to relax smooth muscle, including the coronary arteries, which could theoretically improve blood flow to the heart and reduce angina symptoms. Some early pharmacological studies from the mid-20th century provided preliminary in vitro and animal evidence that khellin and visnagin can cause coronary vasodilation. However, rigorous modern clinical trials in humans are lacking. Bishop's Weed extracts were used in Europe in the 1950s and 1960s for angina, but their use has largely declined, replaced by more effective and better-studied medications such as nitrates and calcium channel blockers. While the traditional use is well documented, the scientific evidence supporting its efficacy for angina is very limited, and it is not recommended as a primary therapy in modern clinical practice. Side effects and drug interactions are also concerns. Overall, Bishop's Weed's use for angina is primarily justified by tradition rather than robust scientific validation.

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