Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Trans-pterostilbene is a naturally occurring compound similar in structure to resveratrol, found in blueberries and Pterocarpus marsupium. Its use for aging prevention is primarily based on scientific evidence from preclinical studies, with limited human data. In animal models and in vitro studies, trans-pterostilbene acts as a potent antioxidant and anti-inflammatory agent, both of which are mechanisms implicated in aging. Research suggests that it activates sirtuin pathways (especially SIRT1), involved in cellular health and longevity, much like resveratrol. Additionally, trans-pterostilbene appears to improve mitochondrial function and reduce oxidative stress, both considered hallmarks of aging.

However, there are few robust clinical trials in humans specifically examining its effects on aging or lifespan. Small studies have suggested potential benefits in improving metabolic parameters and cognitive function, but direct evidence of anti-aging effects in humans is lacking. The compound boasts better bioavailability than resveratrol, which has spurred interest in its potential as a nutraceutical for healthy aging. Despite its promise in laboratory settings, its efficacy and safety for preventing aging in humans remains to be conclusively demonstrated. Thus, while the scientific rationale exists and preclinical data are promising, clinical validation is still limited, warranting a moderate-low evidence rating.

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