Evidence supporting the use of: Folate
For the body system: Uterus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Folate (vitamin B9) is scientifically validated as an important nutrient for supporting the female reproductive system, particularly in relation to the uterus and pregnancy. Folate is essential for DNA synthesis, cell division, and tissue growth—processes that are critical during periods of rapid cell proliferation such as embryogenesis and placental development. Adequate folate levels before and during early pregnancy are proven to reduce the risk of neural tube defects (NTDs) in the developing fetus, which indirectly supports uterine health and overall reproductive outcomes. Multiple clinical guidelines, including those from the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO), recommend folate supplementation for women of childbearing age to prevent NTDs. While most of the scientific focus is on fetal development, the underlying mechanisms—namely, supporting proper cellular function and tissue growth—are directly relevant to the uterus, especially during the preconception and pregnancy periods. There is less evidence for a direct effect of folate on non-pregnant uterine health, but its role in supporting reproductive tissues and preventing pregnancy complications is well established. Therefore, folate’s use to support the uterus is grounded in robust scientific evidence, particularly regarding reproductive health and pregnancy.

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