Evidence supporting the use of: Hesperidin
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hesperidin is a flavonoid commonly found in citrus fruits, and its use for supporting capillary health has both scientific and traditional roots. Scientifically, hesperidin has been studied for its effects on capillary permeability and fragility. Several clinical studies, particularly in Europe, have evaluated hesperidin (often combined with diosmin) for the treatment of chronic venous insufficiency, hemorrhoidal disease, and microvascular disorders. These studies suggest that hesperidin can help reduce capillary permeability, strengthen capillary walls, and improve symptoms such as swelling and leg heaviness.

The proposed mechanisms include antioxidant activity, anti-inflammatory effects, and the stabilization of collagen and other components of the capillary wall. Hesperidin appears to decrease the leakage of plasma from capillaries, thereby reducing edema and related symptoms. However, much of the clinical research involves hesperidin in combination with diosmin, making it challenging to isolate hesperidin’s effects alone.

While there is a moderate body of clinical and mechanistic evidence supporting hesperidin’s benefits for capillary and venous health, the quality and size of studies vary. Most data support its use as a supplement for minor vascular problems rather than for serious vascular disease. Thus, the evidence level is rated as moderate (3 out of 5), reflecting reasonable, but not conclusive, support for its use in capillary support.

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