Vitamin E, particularly in the form of mixed tocotrienols, is used in dermatology for its antioxidant properties, which theoretically may help reduce or prevent wrinkles by protecting skin cells from oxidative stress caused by UV radiation and environmental pollutants. Several in vitro and animal studies have shown that tocotrienols possess stronger antioxidant activity than tocopherols (the more common form of vitamin E), and can reduce lipid peroxidation in skin tissues. Some small human studies and clinical trials have investigated topical vitamin E (mainly as tocopherol) in skin care, reporting mild improvements in skin texture, moisture, and signs of photodamage. There is also some evidence that oral supplementation with tocotrienols may improve skin barrier function and reduce markers of oxidative stress, but robust data specifically linking tocotrienol use to reduced wrinkles in humans is limited.

Most of the scientific validation for vitamin E in wrinkle reduction comes from its established role as an antioxidant and its ability to reduce inflammation and support skin healing. However, controlled clinical trials focusing specifically on tocotrienols for wrinkle treatment are sparse, and results are not always consistent. Thus, while there is a plausible scientific rationale and some supportive evidence, the overall quality and quantity of clinical evidence is modest. Vitamin E (in various forms) is commonly found in anti-aging skin care products, but its efficacy for treating established wrinkles remains only moderately supported by science.