Vitamin E, including the alpha tocotrienol form, is sometimes used in skincare products with the aim of reducing wrinkles and signs of aging. There is some scientific rationale for its use: Vitamin E is a potent lipid-soluble antioxidant that can help protect skin cells from oxidative stress induced by ultraviolet (UV) light and other environmental factors, which contribute to skin aging and wrinkle formation. Several in vitro and animal studies have shown that Vitamin E can reduce markers of oxidative damage in the skin and may help prevent collagen breakdown, a process that accelerates wrinkle development. Some small clinical studies have suggested that topical Vitamin E, often in combination with other antioxidants like Vitamin C, may improve skin hydration, smoothness, and the appearance of fine lines when used over several weeks.

However, the evidence specifically for alpha tocotrienol (as opposed to the more common alpha tocopherol) is limited, with most human studies focusing on mixtures of Vitamin E forms or Vitamin E combined with other compounds. The few available clinical studies are generally small, short in duration, and often sponsored by manufacturers. Thus, while there is a plausible scientific basis for Vitamin E's role in skin health and a modest amount of clinical evidence suggesting some benefit, robust, large-scale studies confirming a significant effect on wrinkles are lacking. The evidence for its effectiveness in treating or preventing wrinkles is therefore moderate at best.