Evidence supporting the use of: Ursolic Acid
For the health condition: Wrinkles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ursolic acid is a naturally occurring triterpenoid found in many plants, such as apple peels, rosemary, and holy basil. Its use in skin care, specifically for wrinkles, is supported by some scientific evidence, though it is mostly limited to preclinical (in vitro and animal) studies and a few small human trials.

Research suggests that ursolic acid may help reduce the appearance of wrinkles by promoting collagen synthesis, inhibiting matrix metalloproteinases (MMPs) that degrade collagen, and exerting antioxidant effects. For example, laboratory studies have demonstrated that ursolic acid can stimulate the production of type I collagen in human dermal fibroblasts and reduce the activity of enzymes that break down the skin’s extracellular matrix. These mechanisms are relevant since decreased collagen and increased matrix degradation contribute to the formation of wrinkles.

Some small clinical studies and cosmetic formulations have reported modest improvements in skin elasticity and reduction in wrinkle depth following topical application of ursolic acid or plant extracts rich in this compound. However, large-scale, well-controlled human studies are lacking, and the evidence is not as robust as for other anti-aging ingredients like retinoids or peptides.

Overall, the scientific evidence for ursolic acid’s anti-wrinkle effects is promising but limited, justifying a moderate evidence rating. More clinical research is needed to establish its efficacy and optimal usage in humans.

More about Ursolic Acid
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Products containing Ursolic Acid

We currently have no products on Caring Sunshine that contain this ingredient.