Ursane-type triterpenoids, such as ursolic acid, are naturally occurring compounds found in a variety of plants including apples, rosemary, and holy basil. There is some scientific evidence supporting their use in the management of skin aging and wrinkles, though the evidence is still preliminary and mainly based on in vitro studies, animal models, and a limited number of small human trials.

The proposed mechanisms for ursane-type triterpenoids in wrinkle reduction include their anti-inflammatory, antioxidant, and collagen-stimulating properties. Studies have shown that ursolic acid can inhibit the activity of enzymes that degrade collagen and elastin, such as matrix metalloproteinases (MMPs), which are upregulated by ultraviolet (UV) exposure and contribute to wrinkle formation. Additionally, ursolic acid has been shown to promote the synthesis of collagen and other extracellular matrix components in cultured skin cells.

Some topical formulations containing ursolic acid have demonstrated modest improvements in skin elasticity and reduction in wrinkle depth in small-scale clinical studies. However, these studies are limited by small sample sizes, short durations, and variability in formulation and dosage. As a result, while there is a scientific rationale for the use of ursane-type triterpenoids in wrinkle management, robust clinical evidence is lacking, and larger, well-controlled trials are needed to firmly establish efficacy.