Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nicotinamide Mononucleotide (NMN) is a precursor to nicotinamide adenine dinucleotide (NAD+), a molecule crucial for cellular metabolism and energy production. Interest in NMN as a supplement for skin health, including wrinkle reduction, stems from its role in supporting cellular repair and its involvement in sirtuin activation—proteins linked to DNA repair and cellular longevity. Preclinical animal studies suggest that increased NAD+ levels may mitigate some aspects of skin aging, such as loss of elasticity and increased wrinkling, mainly by enhancing DNA repair and improving cellular function in dermal cells.

However, direct evidence in humans is limited. A handful of in vitro (cell culture) and animal studies indicate that boosting NAD+ using NMN or related compounds may help reduce oxidative stress and inflammation in skin cells, potentially slowing extrinsic aging processes. Human clinical trials specifically examining NMN for wrinkle reduction are lacking, and most evidence is extrapolated from broader data on NAD+ metabolism.

In summary, while there is a scientific rationale for NMN’s potential benefit in supporting skin health and possibly reducing wrinkles, the current level of direct scientific evidence is preliminary (rated 2/5). More robust, well-controlled human trials are needed to confirm efficacy for this specific indication.

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