Evidence supporting the use of: Lycopene
For the health condition: Wrinkles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lycopene, a carotenoid found predominantly in tomatoes, has been studied for its antioxidant properties and potential skin benefits, particularly in relation to photoaging and wrinkles. Scientific evidence suggests that lycopene may help protect the skin from oxidative stress caused by ultraviolet (UV) radiation, which is a major contributor to the formation of wrinkles. Several small-scale clinical trials and in vitro studies have demonstrated that oral or topical lycopene supplementation can reduce markers of skin damage, improve skin texture, and decrease the depth of wrinkles. For example, a randomized controlled trial published in British Journal of Dermatology (2008) showed that subjects consuming a lycopene-rich tomato paste had less UV-induced erythema and improved skin texture compared to controls.

However, the strength of the evidence is still moderate. Most studies have relatively small sample sizes, short durations, and utilize combinations of antioxidants (such as lycopene with other carotenoids or vitamins), making it difficult to isolate lycopene’s effect. There is also a lack of large, long-term randomized controlled trials specifically targeting wrinkle reduction as a primary endpoint. Nonetheless, the available evidence supports a role for lycopene in skin photoprotection, which indirectly relates to wrinkle prevention and reduction. In summary, lycopene’s use for supporting or treating wrinkles is justified by moderate scientific evidence, primarily due to its antioxidant activity and protective effects against photoaging.

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