Evidence supporting the use of: Grape
For the health condition: Wrinkles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Grapes, particularly their seeds and skins, contain high levels of polyphenols, including resveratrol, proanthocyanidins, and other antioxidants. Scientific studies have demonstrated that these compounds can help protect the skin from oxidative stress and UV-induced damage, two significant contributors to skin aging and wrinkle formation. Topical application or oral supplementation of grape-derived extracts has shown promising anti-aging effects in both in vitro and in vivo studies. For example, resveratrol has been found to improve the appearance of fine lines and wrinkles by stimulating collagen production and reducing inflammation in the skin. Grape seed extract, rich in proanthocyanidins, has demonstrated the ability to scavenge free radicals and protect the skin’s structural integrity, further contributing to its potential in wrinkle prevention and treatment.

However, while laboratory and animal studies are supportive, robust clinical trials on humans are somewhat limited. Some small human studies and cosmetic product trials have reported improvements in skin elasticity and reduction in wrinkle depth after using grape-derived ingredients, but larger-scale, long-term studies are needed to confirm these effects. Overall, the use of grape extracts for supporting or treating wrinkles is supported by a moderate level of scientific evidence, primarily based on their antioxidant and anti-inflammatory properties, but more clinical validation is warranted for definitive claims.

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