Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Equol is a metabolite of the soy isoflavone daidzein and acts as a selective estrogen receptor modulator with antioxidant properties. Its use to support or treat wrinkles has a scientific basis, primarily due to its affinity for estrogen receptors in the skin, which are known to decline with age and contribute to cutaneous aging. Several in vitro and clinical studies have investigated topical and oral equol's effects on skin health. For example, a double-blind, placebo-controlled study demonstrated that topical equol application improved skin firmness, reduced wrinkle depth, and enhanced hydration in postmenopausal women compared to placebo. Mechanistically, equol is thought to stimulate collagen synthesis, inhibit matrix metalloproteinases (which degrade collagen), and reduce oxidative stress, all of which are implicated in wrinkle formation. However, while there is promising evidence from small-scale human trials and robust laboratory studies, large-scale, long-term randomized controlled trials are still lacking. Thus, while the scientific rationale is strong and early data are supportive, the overall strength of evidence is moderate (rated 3 out of 5), and further research is needed to confirm its long-term efficacy and safety for treating wrinkles in diverse populations.

More about Equol (proprietary)
More about Wrinkles

Other ingredients used for Wrinkles

Other health conditions supported by Equol (proprietary)

Products containing Equol (proprietary)

Nature's Sunshine Equolibrium™