Evidence supporting the use of: Collagen
For the health condition: Wrinkles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Collagen is widely used in skincare and dietary supplements to support or treat wrinkles, with its application rooted in both scientific investigation and marketing. Collagen is the most abundant protein in the skin, providing structure, elasticity, and firmness. As we age, natural collagen production declines, contributing to wrinkle formation and skin laxity. Topical collagen in creams is unlikely to penetrate the skin deeply due to its large molecular size; thus, its effects are largely limited to hydration or forming a protective film.

Oral collagen supplementation, however, has demonstrated some scientific support. Several randomized, placebo-controlled studies have reported that daily ingestion of hydrolyzed collagen peptides (typically 2.5–10g per day) for 4–12 weeks can improve skin elasticity, hydration, and the appearance of wrinkles in middle-aged women. Proposed mechanisms include stimulation of fibroblasts to produce more endogenous collagen, as well as elastin and hyaluronic acid.

Nevertheless, the evidence is not unequivocal. Most studies are small, short-term, and sometimes funded by collagen manufacturers, introducing potential bias. Systematic reviews and meta-analyses acknowledge modest benefits, but emphasize the need for more rigorous and long-term trials. In summary, oral collagen supplementation for wrinkles has a moderate level of scientific validation, with evidence strongest for hydrolyzed forms and in specific populations.

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