Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Antioxidants are commonly used in both topical and oral formulations to help reduce or prevent wrinkles, and there is a moderate level of scientific evidence supporting their role in skin aging. Wrinkles are primarily caused by intrinsic aging and extrinsic factors such as UV radiation, which leads to oxidative stress and the generation of reactive oxygen species (ROS) in the skin. These ROS can damage collagen and elastin fibers, accelerate skin aging, and contribute to wrinkle formation.

Scientific studies have shown that antioxidants such as vitamin C, vitamin E, polyphenols, and coenzyme Q10 can neutralize ROS, thereby reducing oxidative damage and slowing the appearance of wrinkles. Several randomized controlled trials and in vitro studies suggest that topical antioxidants can improve skin texture, reduce fine lines, and enhance collagen synthesis. For example, topical vitamin C has been shown to increase collagen production and decrease the depth of wrinkles. Oral supplementation with antioxidants (like carotenoids and polyphenols) may also provide some photo-protective effects, although evidence for direct wrinkle reduction is less robust compared to topical applications.

However, the term "antioxidant (unspecified)" is broad, and not all antioxidants are equally effective or well-studied for wrinkle prevention or treatment. Overall, while there is scientific validation for the use of certain antioxidants in managing wrinkles, the strength of evidence varies depending on the specific antioxidant and its mode of delivery.

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