Evidence supporting the use of: Vitamin B6
For the health condition: Worry

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

There is some emerging scientific evidence suggesting that vitamin B6 (pyridoxine) may play a role in supporting mental health, particularly in the context of anxiety and worry. Vitamin B6 is essential for the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which are involved in mood regulation and stress response. Low levels of B6 have been associated with increased symptoms of anxiety and mood disorders in observational studies.

A 2022 randomized controlled trial published in Human Psychopharmacology found that high-dose vitamin B6 supplementation (100 mg/day for one month) led to self-reported reductions in anxiety among young adults, possibly due to increased GABAergic inhibitory neurotransmission. However, the effect size was modest, and the study design had limitations, including reliance on self-report measures and a relatively short intervention period.

Overall, while there is a plausible biological rationale and some preliminary clinical evidence for the use of vitamin B6 in managing worry or anxiety, the evidence base is still limited and not conclusive. Larger and more rigorous trials are needed to confirm efficacy and establish appropriate dosing. At present, vitamin B6 supplementation for worry or anxiety should be approached with caution and ideally under the guidance of a healthcare professional.

More about vitamin B6
More about Worry

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