Synopsis

Source of validity: Scientific
Rating (out of 5): 2

5-HTP (5-hydroxytryptophan) is an amino acid precursor to serotonin, a neurotransmitter involved in mood regulation. Its use to support or treat "worry" (often overlapping with conditions such as anxiety) has some scientific rationale. Several small-scale clinical trials have explored 5-HTP’s effects on mood and anxiety, with some demonstrating modest benefits in reducing symptoms of anxiety, panic disorder, and even some depressive symptoms. The rationale is that by increasing serotonin synthesis in the brain, 5-HTP may help stabilize mood and reduce excessive worry.

However, the current body of evidence is limited. Most studies are small, of short duration, and often use mixed populations or combine 5-HTP with other nutrients, making it difficult to isolate its effects. Systematic reviews note a lack of large, well-controlled studies. The evidence is better for depression than for anxiety or worry specifically, but the overlap in serotonin’s role in both conditions provides a plausible mechanism.

Significant safety concerns exist, particularly at higher doses or when combined with other serotonergic agents due to the risk of serotonin syndrome. 5-HTP is not FDA-approved for anxiety or worry, and its use should be monitored by healthcare professionals. In summary, there is some scientific support for 5-HTP in reducing worry, but the evidence is weak to moderate and does not justify strong recommendations for its use in this context.

More about 5-Hydroxytryptophan (5-HTP)
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Nature's Sunshine 5-HTP Power