Platycodon grandiflorus, commonly known as balloon flower, has a long history of use in traditional Chinese medicine (TCM) as "Jiegeng." Traditionally, it is employed to treat respiratory conditions such as cough, phlegm, sore throat, and wheezing. The root is believed to help "open up" the lungs, facilitate the flow of qi, and expel phlegm, thereby alleviating symptoms like wheezing. Ancient medical texts and TCM formularies frequently include Platycodon as a component in herbal combinations for respiratory complaints.

From a modern research perspective, there is preliminary evidence that Platycodon root contains saponins and other compounds with anti-inflammatory, expectorant, and possibly bronchodilatory effects. Several in vitro and animal studies have demonstrated that extracts of Platycodon may reduce airway inflammation, inhibit allergic responses, and facilitate mucus clearance. However, robust clinical trials in humans specifically addressing wheezing or asthma are lacking. Most of the evidence remains preclinical or based on traditional usage patterns rather than rigorous scientific validation.

In summary, the use of Platycodon for wheezing is primarily rooted in traditional practice, supported by some promising but limited pharmacological studies. High-quality human clinical trials are needed to establish efficacy and safety for this indication.