Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Irvingia gabonensis, commonly known as African mango, has garnered attention as a weight loss supplement. Its use for weight management is primarily supported by preliminary scientific evidence rather than a long-standing traditional use for this purpose. Several small-scale randomized controlled trials (RCTs) have investigated Irvingia gabonensis seed extracts in overweight or obese adults. Some of these studies, such as a 2009 trial published in Lipids in Health and Disease, reported modest reductions in body weight, waist circumference, and improvements in lipid profiles compared to placebo over a period of 10 weeks. However, these studies are limited by small sample sizes, short durations, and potential conflicts of interest.

Proposed mechanisms include modulation of adipogenesis, inhibition of fat cell growth, and impacts on leptin and adiponectin levels, as well as fiber content that may reduce appetite. Despite these positive findings, a 2013 systematic review highlighted that the evidence is of low quality, and the clinical significance of the effects is uncertain. Major regulatory and health organizations, including the National Center for Complementary and Integrative Health (NCCIH), note that further independent, large-scale, and long-term studies are needed to confirm efficacy and safety. Therefore, while there is some scientific basis for weight loss claims, the overall strength and reliability of the evidence remain weak.

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