Evidence supporting the use of: Garcinia
For the health condition: Weight Loss

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Garcinia, particularly Garcinia cambogia, is a tropical fruit whose rind contains hydroxycitric acid (HCA). It gained popularity as a weight loss supplement in the 1990s. Scientific interest was based on early animal and in vitro studies suggesting that HCA could inhibit an enzyme (ATP citrate lyase) involved in fat production and might suppress appetite by increasing serotonin levels. However, human clinical trials have produced inconsistent results. Several randomized controlled trials have assessed Garcinia cambogia's ability to promote weight loss. Meta-analyses, such as a 2011 review published in the Journal of Obesity, concluded that while there is a statistically significant difference in weight loss compared to placebo, the effect is small (<2 pounds on average) and not likely to be clinically meaningful. Many studies also noted high dropout rates and gastrointestinal side effects. Furthermore, the methodological quality of studies is often low, with small sample sizes and short durations. Regulatory agencies and scientific reviews generally do not endorse Garcinia cambogia as an effective weight loss aid. In summary, while there is a scientific rationale for its use, the actual evidence from human trials is weak and inconsistent, leading to a low overall evidence rating for its effectiveness in weight loss.

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