Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Conjugated linoleic acid (CLA) is a group of fatty acid isomers found naturally in meat and dairy products from ruminant animals. Its use for weight loss is primarily supported by scientific interest, with multiple clinical studies and meta-analyses exploring its potential effects. Several randomized controlled trials have examined CLA supplementation in humans, with some reporting modest reductions in body fat, particularly in overweight or obese individuals. The mechanisms proposed include increased energy expenditure, enhanced fat oxidation, and inhibition of fat storage in adipocytes.

However, the magnitude of these effects is generally small. For example, a 2015 meta-analysis published in the European Journal of Nutrition found that CLA supplementation led to a statistically significant but clinically modest reduction in body fat (about 1.3 kg over 6 months) compared to placebo. Other studies have shown no effect, or effects that are not sustained beyond six months. Additionally, some research has raised concerns about adverse effects, such as insulin resistance or increased markers of inflammation, particularly with certain CLA isomers.

In summary, while there is some scientific evidence suggesting that CLA may aid in reducing body fat, the overall benefits appear limited and variable among individuals. The evidence does not support its use as a standalone or primary weight loss intervention. Its use is not based on traditional medicine but rather on experimental and clinical research over the past few decades.

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