Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Coleus forskohlii is an herb traditionally used in Ayurvedic medicine for various ailments, but its use for weight loss is based primarily on emerging scientific evidence rather than historical tradition. The root of Coleus forskohlii contains forskolin, a compound thought to activate the enzyme adenylate cyclase, thereby increasing cellular levels of cyclic AMP (cAMP). This mechanism is hypothesized to enhance fat breakdown and promote weight loss. Several small-scale, short-duration clinical trials have investigated Coleus forskohlii’s effect on body composition in overweight and obese individuals. The results are mixed: some studies report modest reductions in body fat percentage and fat mass, while others show no significant effect on body weight or appetite suppression. Meta-analyses and systematic reviews generally conclude that the evidence supporting Coleus forskohlii for weight loss remains weak, with limited clinical significance and methodological limitations (e.g., small sample sizes, short study durations, and variable dosages). Reported side effects are generally mild but can include gastrointestinal symptoms and increased heart rate. Overall, while there is some scientific interest and preliminary evidence suggesting a potential role for Coleus forskohlii in weight management, the quality and consistency of the data are insufficient to support its use as a reliable weight-loss supplement. More rigorous, large-scale clinical trials are needed to clarify its efficacy and safety profile.

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