Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Methionine is an essential amino acid that plays a crucial role in protein synthesis and various metabolic processes. Its use to support or treat wasting—such as in muscle wasting (cachexia), malnutrition, or chronic illness—is based on the biological necessity of adequate amino acids for maintaining or rebuilding lean body mass. Scientific studies indicate that protein and amino acid supplementation, including methionine, may benefit individuals experiencing wasting due to inadequate dietary intake or increased metabolic demands. However, the direct evidence specifically isolating methionine as a therapeutic agent for wasting is limited, with most research focusing on general protein or essential amino acid mixtures rather than methionine alone.

Some animal studies and clinical observations suggest that methionine supplementation can help prevent muscle breakdown and support recovery in malnourished states, but robust randomized controlled trials in human populations are lacking. Furthermore, excessive methionine intake can have adverse effects, such as increasing homocysteine levels, which may carry cardiovascular risks. Therefore, while there is a scientific rationale for ensuring sufficient methionine intake as part of overall protein nutrition, targeted methionine supplementation for wasting is not strongly validated, and its evidence rating is moderate to low.

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Other ingredients used for Wasting

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