Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Creatine monohydrate is supported by scientific evidence for use in treating or supporting muscle wasting (sarcopenia or cachexia) associated with certain medical conditions. Muscle wasting can occur due to aging, immobilization, chronic illnesses like cancer, HIV/AIDS, or neuromuscular diseases. Creatine is a naturally occurring compound in the body that plays a crucial role in energy production, particularly in muscle cells. Supplementation with creatine monohydrate has been shown in multiple randomized controlled trials and meta-analyses to help increase muscle mass, strength, and functional performance in individuals experiencing muscle wasting, especially when combined with resistance training.

For example, studies in older adults have demonstrated that creatine supplementation can attenuate muscle loss and improve muscle function. In patients with muscular dystrophy, HIV, and cancer cachexia, creatine has shown modest benefits in maintaining or increasing lean body mass and improving quality of life. The mechanisms are believed to involve improved cellular energy availability, increased satellite cell proliferation, and enhanced muscle protein synthesis.

While creatine is not a cure for underlying diseases causing wasting, its use as an adjunctive therapy is increasingly recognized in clinical guidelines for certain populations. The safety profile of creatine is well established, with few serious adverse effects reported in clinical use. Overall, creatine monohydrate is a scientifically validated adjunct for managing muscle wasting in specific contexts, earning a relatively high evidence rating for this use.

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