Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Creatine and leucine are two distinct compounds, both of which have been studied for their roles in supporting muscle mass and function, particularly in conditions characterized by muscle wasting (cachexia, sarcopenia, or wasting syndromes). There is substantial scientific evidence supporting the use of both creatine and leucine (especially as part of branched-chain amino acids) for preserving or improving muscle mass in various populations, including elderly individuals, patients with chronic illnesses, and those experiencing disuse atrophy.

Creatine supplementation has been shown in multiple randomized controlled trials and meta-analyses to increase muscle mass, strength, and physical performance, particularly when combined with resistance training. Its mechanism involves increasing phosphocreatine stores in muscle, which enhances energy availability and supports muscle protein synthesis.

Leucine, an essential branched-chain amino acid, is a key regulator of the mTOR pathway and muscle protein synthesis. Numerous studies have demonstrated that leucine supplementation, either alone or as part of protein blends, can stimulate muscle protein synthesis and help attenuate muscle loss in catabolic states.

While there is less direct research on a combined "creatine leucine" compound, the individual evidence for both ingredients is strong, and some studies have explored the additive or synergistic effects of creatine and amino acids for muscle health. Therefore, the use of creatine and leucine to support or treat wasting is justified by scientific evidence, with moderate to strong support (rated 4/5).

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