Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Creatine leucinate is a compound consisting of creatine bound to the amino acid leucine. While creatine itself is well-studied for its role in muscle metabolism and performance, and leucine is known to stimulate muscle protein synthesis, the specific combination—creatine leucinate—has limited direct clinical evidence in the context of treating or supporting wasting conditions (such as sarcopenia or cachexia). However, the rationale for its use is based on the established benefits of its components.

Creatine supplementation has demonstrated moderate efficacy (evidence level 2/5) in slowing muscle loss and improving muscle strength and function in various clinical populations, including older adults and patients with wasting diseases. Leucine, as a branched-chain amino acid, also contributes to muscle maintenance by activating the mTOR pathway, which promotes protein synthesis.

A few preclinical and small-scale human studies suggest that combining creatine and leucine may have additive or synergistic effects on muscle protein synthesis and muscle mass preservation. However, there is a lack of large, high-quality randomized controlled trials evaluating creatine leucinate specifically in wasting conditions. Most evidence is extrapolated from studies on the separate components. Thus, while the scientific rationale exists, direct evidence is currently modest, and further research is needed to establish its efficacy for wasting disorders.

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