Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Creatine, including forms like creatine gluconate, has been investigated for its potential to counteract muscle wasting (cachexia) associated with various conditions such as chronic illness, malnutrition, and aging (sarcopenia). The rationale stems from creatine’s well-established role in muscle energy metabolism; it helps replenish ATP in muscle tissue, thus supporting muscle function and potentially limiting atrophy. Several studies on creatine monohydrate—the most researched form—have shown moderate benefits in preserving or increasing lean body mass in patients with muscular dystrophies, older adults, and individuals recovering from immobilization or illness-induced wasting. Meta-analyses suggest that creatine supplementation can result in small but significant improvements in muscle mass and strength, particularly when combined with resistance training.

However, evidence specifically for creatine gluconate is limited, as most clinical trials have used creatine monohydrate. The generalizability of findings to creatine gluconate is presumed based on similar bioactivity, but direct comparative studies are lacking. No major guidelines currently recommend creatine (in any form) as a first-line treatment for wasting, but it is sometimes used as an adjunct. Overall, scientific support exists but is not robust, and more research is needed, particularly on non-monohydrate forms like gluconate.

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