Evidence supporting the use of: Creatine
For the health condition: Wasting
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Creatine has scientific support for its use in the management of muscle wasting (also known as cachexia or sarcopenia) associated with various conditions, such as muscular dystrophies, aging, and chronic diseases. Numerous clinical trials and meta-analyses have investigated creatine supplementation in patients with muscle-wasting disorders. The evidence suggests that creatine can improve muscle mass, strength, and physical performance in these populations, particularly when combined with resistance training.
For example, randomized controlled trials in patients with muscular dystrophy, HIV-associated wasting, and older adults have shown modest but significant increases in lean body mass and muscle strength after creatine supplementation. A 2013 meta-analysis published in PLoS One (Brosnan and Brosnan) concluded that creatine supplementation is effective at increasing muscle strength and mass in people with muscle-wasting conditions, with a favorable safety profile. The mechanism is believed to involve enhanced phosphocreatine stores, improved energy metabolism, and possible anti-inflammatory effects.
While creatine is not a cure for wasting disorders and may not work for all patients or all conditions, the consensus in the scientific literature is that it offers a beneficial adjunct to physical therapy or nutritional support in many cases. However, responses can vary, and more research is needed in certain patient groups. Overall, the evidence justifies the use of creatine as a supportive therapy for muscle wasting with a moderate to strong level of scientific validation.
Other ingredients used for Wasting
acetyl l-carnitinealpha-ketoglutarate (AKG)
apricot
astragalus
bovine liver
branched-chain amino acids
colostrum
cordyceps
creatine monohydrate
l-leucine
lentinula edodes mycelia
magnesium
medium chain triglycerides (MCT)
vitamin B12
whey protein
zinc
17a-di methyl-bol
17beta-(1-ketoethyl)-androstane-3-one, 17a-ol
2, 17a-dimethyl-17b-hydroxy-5a-androst-2-ene
2a 17a -dimethyl 17a hydroxy, 5a etiocholan 3-one
2, 17a-dimethyl-17b-hydroxy-5a-androstan-1-ene-3-one
2a, 17a-dimethyl-17b-hydroxy-5a-androstan-3-one
Animal Tissue
Arginine Creatine
Albumin
Alpha-ketoisocaproic acid
Algal protein
Arginine alpha-ketoisocaproate
Animal protein
Beef Protein
Beef
Beef liver
Bone Marrow
BCAA
Codonopsis
Creatine
Chicken
Deer Velvet
Eurycoma Longifolia
Guanidinoacetic acid
glucose
Isoleucine
Other health conditions supported by Creatine
Alzheimer's DiseaseAthletic and Exercise Aids
Depression
Diabetes
Fatigue
Inflammation
Memory and Brain Function
Migraine
Muscle Tone (lack of)
Muscular Dystrophy
Parkinson's Disease
Wasting