Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Creatine has scientific support for its use in the management of muscle wasting (also known as cachexia or sarcopenia) associated with various conditions, such as muscular dystrophies, aging, and chronic diseases. Numerous clinical trials and meta-analyses have investigated creatine supplementation in patients with muscle-wasting disorders. The evidence suggests that creatine can improve muscle mass, strength, and physical performance in these populations, particularly when combined with resistance training.

For example, randomized controlled trials in patients with muscular dystrophy, HIV-associated wasting, and older adults have shown modest but significant increases in lean body mass and muscle strength after creatine supplementation. A 2013 meta-analysis published in PLoS One (Brosnan and Brosnan) concluded that creatine supplementation is effective at increasing muscle strength and mass in people with muscle-wasting conditions, with a favorable safety profile. The mechanism is believed to involve enhanced phosphocreatine stores, improved energy metabolism, and possible anti-inflammatory effects.

While creatine is not a cure for wasting disorders and may not work for all patients or all conditions, the consensus in the scientific literature is that it offers a beneficial adjunct to physical therapy or nutritional support in many cases. However, responses can vary, and more research is needed in certain patient groups. Overall, the evidence justifies the use of creatine as a supportive therapy for muscle wasting with a moderate to strong level of scientific validation.

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