Evidence supporting the use of: Amino Acid (unspecified)
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Wasting syndrome, also known as cachexia, is characterized by involuntary weight loss, muscle wasting, and malnutrition, often seen in chronic illnesses such as cancer, HIV/AIDS, and advanced heart failure. Amino acids, as the building blocks of proteins, have a well-established role in supporting muscle mass and overall nutritional status. Scientific studies have investigated both individual and mixed (unspecified) amino acid supplementation to counteract the loss of lean body mass in wasting conditions. Research demonstrates that providing essential amino acids can stimulate muscle protein synthesis and may help attenuate muscle breakdown in patients experiencing wasting.

Clinical trials and meta-analyses indicate that amino acid supplementation can improve nitrogen balance, muscle mass, and sometimes functional outcomes in patients with cachexia, especially when combined with overall nutritional support and resistance exercise. However, results are variable, and the magnitude of benefit depends on factors such as the underlying disease, the type and dose of amino acids used, and patient nutritional status. While not a standalone cure, amino acid supplementation is included in many clinical guidelines as a part of a multimodal approach to managing wasting. Thus, the use of (unspecified) amino acids for this purpose is supported by a moderate level of scientific evidence, though further research continues to refine their optimal application.

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