Evidence supporting the use of: Alpha-ketoisocaproic acid
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha-ketoisocaproic acid (KIC) is an intermediate in the metabolism of the essential amino acid leucine. Its use in the context of wasting (such as muscle wasting due to chronic illness, cancer cachexia, or other catabolic states) has some scientific support, though the evidence is moderate rather than robust. KIC is often provided as part of keto acid supplements, sometimes alongside other keto analogues of essential amino acids, to support protein metabolism in situations where muscle breakdown exceeds synthesis.

Several studies have investigated the use of KIC, alone or in combination with other keto acids, particularly in patients with chronic kidney disease or those with severe catabolic states. The rationale is that KIC can be transaminated to leucine, thus serving as a substrate for protein synthesis without contributing to nitrogen load—important for patients who need to limit nitrogen intake. Some clinical trials and animal studies have shown that supplementation with keto acids (including KIC) can help preserve muscle mass, improve nitrogen balance, and decrease muscle protein breakdown in wasting conditions. However, most studies are small, of variable quality, or use KIC as part of a mixture with other keto acids, making it difficult to isolate the effect of KIC alone.

In summary, there is moderate scientific evidence supporting the use of alpha-ketoisocaproic acid in the management of wasting, particularly as part of broader keto acid supplementation strategies. However, more rigorous, large-scale studies are needed to fully establish its efficacy and optimal use.

More about Alpha-ketoisocaproic acid
More about Wasting

Other health conditions supported by Alpha-ketoisocaproic acid

Athletic and Exercise Aids
Body Building
Exercise
Muscle Tone (lack of)
Wasting

Products containing Alpha-ketoisocaproic acid

We currently have no products on Caring Sunshine that contain this ingredient.