Synopsis

Source of validity: Scientific
Rating (out of 5): 3

2α,17α-dimethyl-17α-hydroxy-5α-etiocholan-3-one is better known as methyl-1-testosterone, a synthetic anabolic-androgenic steroid (AAS). The compound has been investigated and used in the context of muscle wasting (cachexia) associated with chronic illnesses such as HIV/AIDS, cancer, and other catabolic states. Anabolic steroids, in general, have scientific backing for their efficacy in promoting the retention of lean body mass and increasing muscle strength in wasting conditions. Clinical guidelines and systematic reviews have shown that certain oral and injectable anabolic steroids can improve body weight, muscle mass, and sometimes quality of life in patients suffering from wasting syndromes.

Specifically, methyl-1-testosterone has not been as extensively studied as other AAS (such as oxandrolone or nandrolone) in large, placebo-controlled clinical trials for wasting. Most available data comes from the broader class of anabolic steroids to which it belongs. These compounds exert their effects via androgen receptor activation, stimulating protein synthesis and reducing muscle breakdown. However, methyl-1-testosterone is not approved by regulatory agencies for medical use due to concerns about hepatotoxicity and other adverse effects. Its use in clinical practice is rare, and it is mainly encountered as an illicit compound in bodybuilding communities.

In summary, while the use of anabolic steroids for wasting has a scientific basis, the specific evidence for methyl-1-testosterone is limited, and clinical use is not recommended due to safety concerns. The rating reflects the broader evidence for the class, not for this specific molecule.

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