Pycnogenol is a standardized extract from the bark of the French maritime pine (Pinus pinaster), and it is used to support vascular and venous health, including the management of chronic venous insufficiency (CVI) and varicose veins. Several clinical studies and meta-analyses have demonstrated that Pycnogenol can improve symptoms of CVI, such as leg heaviness, edema, and pain. The proposed mechanisms involve its potent antioxidant properties, anti-inflammatory effects, and ability to stabilize capillary walls, which may reduce capillary permeability and improve microcirculation.

A 2012 meta-analysis (Cesarone et al., 2012) reviewed randomized controlled trials and concluded that Pycnogenol significantly reduced leg swelling and improved venous tone compared to placebo. Another systematic review (Belcaro et al., 2008) also found consistent benefits in venous disorders. The evidence base consists of multiple small-to-moderate-sized trials, many of which show statistically significant results, though some authors note the need for larger and longer-term studies to confirm these effects.

In summary, Pycnogenol is scientifically validated for venous support, with evidence supporting its use in improving symptoms of chronic venous insufficiency and related conditions.