Evidence supporting the use of: Citrus sinensis
For the body system: Veins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Citrus sinensis, commonly known as sweet orange, has some scientific backing for its use in supporting the veins and vascular health, primarily due to its content of flavonoids such as hesperidin and diosmin. Several clinical studies and reviews have documented the beneficial effects of these citrus-derived compounds on chronic venous insufficiency (CVI) and related conditions. Hesperidin, particularly when combined with diosmin, has been shown to improve venous tone, decrease capillary permeability, and reduce symptoms such as leg swelling and heaviness. These effects are thought to result from antioxidant, anti-inflammatory, and vasoprotective properties of the flavonoids. A notable body of evidence comes from studies on micronized purified flavonoid fraction (MPFF), which often contains hesperidin from Citrus sinensis as a major component. Clinical trials have demonstrated that MPFF can relieve symptoms of CVI and improve quality of life in affected patients. However, it is important to note that while the evidence is promising, most studies are performed with standardized extracts rather than whole fruit or juice, and the effect size is generally moderate. Overall, the use of Citrus sinensis-derived flavonoids for vein support is scientifically justified, but the evidence is not as robust as that for pharmaceutical interventions, and the benefit primarily pertains to specific purified compounds rather than general consumption of the fruit.

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