Evidence supporting the use of: Citrus bioflavonoids
For the body system: Veins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Citrus bioflavonoids are a class of polyphenolic compounds found in citrus fruits like oranges, lemons, and grapefruits. Their use to support the venous system—particularly for conditions like chronic venous insufficiency (CVI) and varicose veins—has some scientific backing. Several clinical studies and reviews have investigated the effects of flavonoids, especially diosmin, hesperidin, and related compounds, on venous tone and capillary permeability. Mechanistically, bioflavonoids are thought to strengthen capillary walls, reduce vascular permeability, and exhibit anti-inflammatory and antioxidant properties that benefit vascular health.

A meta-analysis published in Phytotherapy Research (2015) and reviews in journals like Angiology have reported that micronized purified flavonoid fractions (primarily diosmin and hesperidin) can reduce symptoms such as leg swelling, heaviness, and pain in patients with CVI. However, much of the strongest evidence pertains to specific, concentrated formulations rather than general citrus bioflavonoid supplements. While these findings provide a scientific rationale for their use, the evidence is moderate: sample sizes are often small, and not all studies find significant benefits.

In summary, citrus bioflavonoids have some scientific support for promoting venous health, but the evidence is not unequivocal and is strongest for certain purified flavonoid preparations. Thus, their use for supporting the veins is rated as moderate based on current scientific literature.

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